Recurrent Embryo Implantation Failure
When IVF and ICSI don’t result in a successful embryo implantation and pregnancy, it is called Embryo Implantation Failure.
When IVF and ICSI don’t result in a successful embryo implantation and pregnancy, it is called Embryo Implantation Failure. If this happens more than three times, it is Recurrent Embryo Implantation Failure (RIF).
Why does it happen?
It is usually caused by a deficiency in the embryo’s DNA, but can also be due to genetic and chromosomal abnormalities or the woman’s age, with the likelihood increasing from age 35 upwards.
What can be done to help?
Maternal Blood Tests. These establish the levels of white blood cells and autoantibodies in your blood, and identify if there are any small blood clots. If there are, they can be treated with aspirin or heparin injections
Endometrial Tests. These analyse the tissue’s gene content which can determine many factors that have an impact on implantation. A hysteroscopy or endometrial scratch is recommended if you have previously had scar tissue, a fibroid or polyps in the uterus
Paternal Tests. These will investigate whether the sperm could be the cause of RIF, in which case you may benefit from ICSI
Genetic Screening. This will provide important information about the embryos before they are implanted, so that the ones with best chance of success can be used
Laser-Assisted Hatching. This is a chemical or physical treatment that is performed immediately before embryo transfer that improves the chances of successful implantation
Egg Donation. It may be the quality of the eggs that is causing RIF, in which case egg donation from a younger donor may prove more successful- particularly if the woman is aged above 35